From hazard analysis to risk control using rapid methods in microbiology: A practical approach for the food industry

From hazard analysis to risk control using rapid methods in microbiology: A practical approach for the food industry

The prevention of foodborne diseases is one of the main objectives of the health authorities. For this purpose, analytical techniques for detecting and / or quantifying the microbiological contamination of food prior to release on the market are required. The management and control of pathogens of food origin have generally been based on conventional detection methodologies, which do not only consume a lot of time and labor, but also involve high consumer material costs. However, this management perspective has changed over time that the food industry requires effective analytical methods that achieve quick results.

This review covers the historical context of traditional methods and their passage in the latest developments of rapid methods and their implementation in the food sector. Improvements and limitations in the detection of the most relevant pathogens are discussed from a perspective applicable to the current situation in the food industry. Given the efforts and recent developments, fast and accurate methods already used in the food industry will also be affordable and portable and provide connectivity in the near future, which improves decision-making and safety throughout the chain Food. A retrospective epidemiological study describing the characteristics, the incidence rates (IR) and the microbiological etiology of the SCAP in Central Australia.

Adult Patients Admitted to Alice Springs Hospital Intensive Care Unit (ICU) between 2011-2014 which has been included the IDSA / ATS definition of the SCAP. Medical records have been examined and compared between Aboriginal and non-Aboriginal patients. Primary results were an incidence rate and microbiological etiology of SCAP. Secondary results were 30 days mortality and a residence time of the ICU and the hospital (LOS).

 

Plancostomycetes as bacteria associated with the host: a perspective that keeps the promise of their future isolates, imitating their aboriginal environmental niches in clinical microbiology laboratories

 

Traditionally recognized as environmental bacteria, plancostomycetes have recently been linked to human pathology as opportunistic pathogens, providing great interest to clinical microbiologists. However, the absence of appropriate culture media limits our future surveys because no plackctomyte has ever been isolated from patient specimens despite multiple attempts. Several plancostomycetes have no cultivable members and are recognized only by detecting and analyzing the sequence of the arrn genes. Cultivated representatives are tedious slow growth bacteria and most of the time culture on synthetic media.

As a result, the provision of environmental and nutritional conditions such as those existing in natural habitat in natural habitat where non-skin / refractory bacteria can be detected could be an option for their potential isolation. As a result, we have systematically examined the different natural plancostomycete habitats, to examine their nutritional requirements, the physicochemical characteristics of their natural ecological niches, the current methods of cultivation of plackcetes and gaps, from a perspective of data collection. to optimize the conditions and the culture protocols of these tedious bacteria.

Plancptomycetes are prevalent in freshwater, seawater and terrestrial environments, mainly associated with particles or organisms such as macroalgae, marine sponges and lichens, depending on the species and polysaccharides metabolizable by their sulfatasis. Most plancostomycetes are developing in poor nutrient oligotrophic environments with a pH ranging from 3.4 to 11, but some strains can also develop in media rich in nutrients such as M600 / M14. In addition, a variation in seasonality of abundance is observed and flowering occurs in the summer-early autumn, correlated with strong algae growth in marine environments. Most placalcètes are mesophilic, but with some plancostomycetes being thermophilic (50 ° C to 60 ° C).

 From hazard analysis to risk control using rapid methods in microbiology: A practical approach for the food industry
From hazard analysis to risk control using rapid methods in microbiology: A practical approach for the food industry

Mini Review: Clinical Routine Microbiology in the Era of Digital Automation and Health

 

Clinical microbiology laboratories are the first line of infectious disease and antibiotic resistance, including new emerging. Although most clinical laboratories are still based on conventional methods, a cascade of technological change, driven by digital imaging and high-speed sequencing, will revolutionize clinical diagnostics management for direct detection of bacteria and susceptibility testing. rapid antimicrobial. IMPORTANT, such technological advances occur in the golden age of machines learning where computers do not act more passively in the mining of data, but once trained, can also help doctors take Decisions on the optimal diagnosis and administration of treatment.

The additional physical integration potential of new technologies in an automation chain, associated with the software to the automatic learning of data analyzes, is seduced and lead to faster management of infectious diseases. However, if, on the one hand, the technological advancement would have a better performance than conventional methods, on the other side, this evolution disputes clinicians in terms of data interpretation and impact on the whole of the Organization and management of the staff of the hospital.

Histamine dihydrochloride

GE0339-1 1
EUR 20

Histamine dihydrochloride

GE0339-25 25
EUR 117.6

Histamine dihydrochloride

GE0339-5 5
EUR 45.1

H89 Dihydrochloride

20-abx076747
  • EUR 811.20
  • EUR 360.00
  • 25 mg
  • 5 mg

MPP dihydrochloride

B6910-10 10 mg
EUR 381.6

MPP dihydrochloride

B6910-50 50 mg
EUR 1413.6

SAG dihydrochloride

GL1175-1MG 1 mg
EUR 234

SAG dihydrochloride

GL1175-5MG 5 mg
EUR 688.8

TMB (dihydrochloride)

HY-15930A 10mM/1mL
EUR 135.6

TMB dihydrochloride

TB0514 1g
EUR 85.06

SAG dihydrochloride

GL1175-1 1
EUR 98.4

SAG dihydrochloride

GL1175-25 25
EUR 334.3

SAG dihydrochloride

GL1175-5 5
EUR 169

IT1t dihydrochloride

B5650-10 10 mg
EUR 385.2
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.

IT1t dihydrochloride

B5650-100 100 mg
EUR 2100
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.

IT1t dihydrochloride

B5650-25 25 mg
EUR 710.4
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.

IT1t dihydrochloride

B5650-5 5 mg
EUR 243.6
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.

IT1t dihydrochloride

B5650-5.1 10 mM (in 1mL DMSO)
EUR 261.6
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.

IT1t dihydrochloride

B5650-50 50 mg
EUR 1232.4
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.

1400W dihydrochloride

2055-25 each
EUR 405.6

1400W dihydrochloride

2055-5 each
EUR 151.2

DMPQ Dihydrochloride

20-abx076714
  • EUR 693.60
  • EUR 326.40
  • 25 mg
  • 5 mg

DMPQ dihydrochloride

B6642-10 10 mg
EUR 223.2

DMPQ dihydrochloride

B6642-5 5 mg
EUR 184.8

GNTI dihydrochloride

B6669-10 10 mg
EUR 459.6

GNTI dihydrochloride

B6669-50 50 mg
EUR 1746

1400W dihydrochloride

B6730-10 10 mg
EUR 170.4
Description: 1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase with Kd value of 7 nM [1]. Inducible nitric oxide synthase (iNOS) is an enzyme catalyzing the production of nitric oxide (NO) and is involved in immune response.

1400W dihydrochloride

B6730-100 100 mg
EUR 873.6
Description: 1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase with Kd value of 7 nM [1]. Inducible nitric oxide synthase (iNOS) is an enzyme catalyzing the production of nitric oxide (NO) and is involved in immune response.

1400W dihydrochloride

B6730-50 50 mg
EUR 525.6
Description: 1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase with Kd value of 7 nM [1]. Inducible nitric oxide synthase (iNOS) is an enzyme catalyzing the production of nitric oxide (NO) and is involved in immune response.

1400W dihydrochloride

GK6799-100MG 100 mg
EUR 661.2

1400W dihydrochloride

GK6799-25MG 25 mg
EUR 274.8

1400W dihydrochloride

GK6799-5MG 5 mg
EUR 136.8

PAβN (dihydrochloride)

HY-101444A 10mM/1mL
EUR 154.8

IT1t (dihydrochloride)

HY-101458A 10mg
EUR 308.4

1400W (Dihydrochloride)

HY-18731 10mM/1mL
EUR 151.2

DAPI (dihydrochloride)

HY-D0814 50mg
EUR 439.2

1400W dihydrochloride

GK6799-100 100
EUR 605.5

1400W dihydrochloride

GK6799-25 25
EUR 228.1

1400W dihydrochloride

GK6799-5 5
EUR 86.5

GGACK Dihydrochloride

1847-5 5 mg
EUR 382.8
Description: A potent and irreversible inhibitor of Urokinase (uPA (IC??<1 µM), Factor VIIa, Factor IXa, Factor Xa, and trypsin.

PPACK Dihydrochloride

1848-5 each
EUR 301.2

GGACK Dihydrochloride

A2582-5 5 mg
EUR 282
Description: A potent and irreversible inhibitor of Urokinase (uPA (IC??<1 µM), Factor VIIa, Factor IXa, Factor Xa, and trypsin.

PPACK Dihydrochloride

A2588-10 10 mg
EUR 423.6
Description: PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human ?-thrombin with inhibition constant Kivalue of 0.24 nM.

PPACK Dihydrochloride

A2588-25 25 mg
EUR 908.4
Description: PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human ?-thrombin with inhibition constant Kivalue of 0.24 nM.

PPACK Dihydrochloride

A2588-5 5 mg
EUR 265.2
Description: PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human ?-thrombin with inhibition constant Kivalue of 0.24 nM.

JDTic (dihydrochloride)

HY-10487 50mg
EUR 1501.2

MS023 (dihydrochloride)

HY-19615B 100mg
EUR 1093.2

DG172 (dihydrochloride)

HY-19737A 50mg
EUR 704.4

GBR 12935 dihydrochloride

B4661-10 10 mg
EUR 129.6

GBR 12935 dihydrochloride

B4661-100 100 mg
EUR 296.4

GBR 12935 dihydrochloride

B4661-50 50 mg
EUR 192

ETP 45835 dihydrochloride

B4938-10 10 mg
EUR 428.4

ETP 45835 dihydrochloride

B4938-50 50 mg
EUR 1608

AZ 10606120 dihydrochloride

B5410-10 10 mg
EUR 408
Description: KD: 1.4 nM and 1.9 nM for human and rat P2X7 receptors, respectivleyThe P2X7 receptor has intriguing biophysical properties, activates a diverse range of cellular events and mediates a wide range of functional effects.

AZ 10606120 dihydrochloride

B5410-50 50 mg
EUR 1531.2
Description: KD: 1.4 nM and 1.9 nM for human and rat P2X7 receptors, respectivleyThe P2X7 receptor has intriguing biophysical properties, activates a diverse range of cellular events and mediates a wide range of functional effects.

CP 99994 dihydrochloride

B5422-10 10 mg
EUR 478.8

CP 99994 dihydrochloride

B5422-50 50 mg
EUR 1824

SB 243213 dihydrochloride

B5444-10 10 mg
EUR 486

SB 243213 dihydrochloride

B5444-50 50 mg
EUR 1802.4

JNJ 5207852 dihydrochloride

B5513-10 10 mg
EUR 289.2

JNJ 5207852 dihydrochloride

B5513-5 5 mg
EUR 180

JNJ 5207852 dihydrochloride

B5513-50 50 mg
EUR 1021.2

A 412997 dihydrochloride

B5639-25 25 mg
EUR 642
Description: A 412997 dihydrochloride is a selective agonist of dopamine D4 receptor with Ki values of 7.9 and 12.1 nM for human and rat D4 receptors, respectively [1]. Dopamine D4 receptor is a G protein-coupled receptor and is activated by dopamine.

A 412997 dihydrochloride

B5639-5 5 mg
EUR 212.4
Description: A 412997 dihydrochloride is a selective agonist of dopamine D4 receptor with Ki values of 7.9 and 12.1 nM for human and rat D4 receptors, respectively [1]. Dopamine D4 receptor is a G protein-coupled receptor and is activated by dopamine.

SA 4503 dihydrochloride

B5778-10 10 mg
EUR 297.6

SA 4503 dihydrochloride

B5778-5.1 10 mM (in 1mL DMSO)
EUR 343.2

SA 4503 dihydrochloride

B5778-50 50 mg
EUR 1069.2

BMS 599626 dihydrochloride

B5792-10 10 mg
EUR 642
Description: BMS 599626 dihydrochloride is a potent and selective inhibitor of EGFR and ErbB2 with IC50 values of 22 and 32 nM, respectively [1].

TC 1698 dihydrochloride

B7089-10 10 mg
EUR 408

TC 1698 dihydrochloride

B7089-50 50 mg
EUR 1531.2

JP 1302 dihydrochloride

B7147-10 10 mg
EUR 466.8

JP 1302 dihydrochloride

B7147-50 50 mg
EUR 1771.2

BYK 191023 dihydrochloride

B7210-10 10 mg
EUR 297.6
Description: IC50: 86 nM for iNOSNO synthases are enzymes responsible for the generation of nitric oxide from the amino acid L-arginine. Once expressed the inducible NO synthase (iNOS) is active and produces ?M concentrations of NO over longer periods.

BYK 191023 dihydrochloride

B7210-5 5 mg
EUR 184.8
Description: IC50: 86 nM for iNOSNO synthases are enzymes responsible for the generation of nitric oxide from the amino acid L-arginine. Once expressed the inducible NO synthase (iNOS) is active and produces ?M concentrations of NO over longer periods.

BYK 191023 dihydrochloride

B7210-50 50 mg
EUR 999.6
Description: IC50: 86 nM for iNOSNO synthases are enzymes responsible for the generation of nitric oxide from the amino acid L-arginine. Once expressed the inducible NO synthase (iNOS) is active and produces ?M concentrations of NO over longer periods.

ARL 17477 dihydrochloride

B7363-10 10 mg
EUR 350.4
Description: ARL 17477 dihydrochloride is a selective and potent neuronal nitrogen oxide synthase (nNOS) inhibitor with IC50 values of 1 and 17?M for nNOS and endothelial NOS, respectively [1].

ARL 17477 dihydrochloride

B7363-50 50 mg
EUR 1264.8
Description: ARL 17477 dihydrochloride is a selective and potent neuronal nitrogen oxide synthase (nNOS) inhibitor with IC50 values of 1 and 17?M for nNOS and endothelial NOS, respectively [1].

PD 168568 dihydrochloride

B7420-10 10 mg
EUR 369.6

PD 168568 dihydrochloride

B7420-50 50 mg
EUR 1363.2

A 943931 dihydrochloride

B7495-10 10 mg
EUR 486
Description: A 943931, is an H4R (one of histamine receptor subtypes) antagonist [1] with high affinities to H4Rs of human (Ki = 5 nM), rat (Ki = 4 nM) and mouse (Kb = 6 nM) [2]. H4R is one of 4 known G-protein-coupled receptors of histamine for histamine to mediate its physiological functions [3].

A 943931 dihydrochloride

B7495-50 50 mg
EUR 1802.4
Description: A 943931, is an H4R (one of histamine receptor subtypes) antagonist [1] with high affinities to H4Rs of human (Ki = 5 nM), rat (Ki = 4 nM) and mouse (Kb = 6 nM) [2]. H4R is one of 4 known G-protein-coupled receptors of histamine for histamine to mediate its physiological functions [3].

PG 01037 dihydrochloride

B7524-10 10 mg
EUR 309.6

PG 01037 dihydrochloride

B7524-25 25 mg
EUR 633.6

PG 01037 dihydrochloride

B7524-5 5 mg
EUR 195.6

WAY 207024 dihydrochloride

B7525-10 10 mg
EUR 576
Description: WAY 207024 dihydrochloride is a potent gonadotropin releasing hormone receptor (GnRH-R) antagonist with IC50 values of 12 and 71 nM for human and rat GnRH receptors, respectively [1].

WAY 208466 dihydrochloride

B7531-10 10 mg
EUR 289.2

WAY 208466 dihydrochloride

B7531-25 25 mg
EUR 582

WAY 208466 dihydrochloride

B7531-5 5 mg
EUR 184.8

WAY 267464 dihydrochloride

B7538-10 10 mg
EUR 556.8

JNJ 10181457 dihydrochloride

B7567-10 10 mg
EUR 466.8

JNJ 10181457 dihydrochloride

B7567-50 50 mg
EUR 1771.2

BMS 470539 dihydrochloride

B7577-10 10 mg
EUR 544.8
Description: BMS 470539 dihydrochloride is a potent and selective melanocortin-1 (MC1) receptor agonist with IC50 of 120 nM [1]. The melanocortin-1 receptor (MC-1R) is a G protein-coupled receptor involved in blocking inflammation and augmenting skin pigmentation [1].

BMS 470539 dihydrochloride

B7577-50 50 mg
EUR 2056.8
Description: BMS 470539 dihydrochloride is a potent and selective melanocortin-1 (MC1) receptor agonist with IC50 of 120 nM [1]. The melanocortin-1 receptor (MC-1R) is a G protein-coupled receptor involved in blocking inflammation and augmenting skin pigmentation [1].

PS 1145 dihydrochloride

B7683-25 25 mg
EUR 428.4

PS 1145 dihydrochloride

B7683-5 5 mg
EUR 164.4

A 331440 dihydrochloride

B7698-10 10 mg
EUR 459.6
Description: A-331440 is described here instead of A-331440 dihydrochloride. A-331440 is an antagonist of non-imidazole histamine H3 receptor with an IC50 value of 22.7 nM for human cortex histamine H3 [1].

A 331440 dihydrochloride

B7698-50 50 mg
EUR 1746
Description: A-331440 is described here instead of A-331440 dihydrochloride. A-331440 is an antagonist of non-imidazole histamine H3 receptor with an IC50 value of 22.7 nM for human cortex histamine H3 [1].

R 1485 dihydrochloride

B7723-10 10 mg
EUR 466.8

R 1485 dihydrochloride

B7723-50 50 mg
EUR 1771.2

DBM 1285 dihydrochloride

B7748-10 10 mg
EUR 517.2

DBM 1285 dihydrochloride

B7748-50 50 mg
EUR 1987.2

LDN 209929 dihydrochloride

B7785-10 10 mg
EUR 466.8
Description: Target: haspin kinaseIC50: 55 nMLDN 209929 dihydrochloride is a selective and potent haspin kinase inhibitor with IC50 value of 55 nM [1]. LDN 209929 dihydrochloride displays 180-fold selectivity on haspin kinase over DYRK2 [1].

LDN 209929 dihydrochloride

B7785-50 50 mg
EUR 1771.2
Description: Target: haspin kinaseIC50: 55 nMLDN 209929 dihydrochloride is a selective and potent haspin kinase inhibitor with IC50 value of 55 nM [1]. LDN 209929 dihydrochloride displays 180-fold selectivity on haspin kinase over DYRK2 [1].

GBR 13069 dihydrochloride

B6296-10 10 mg
EUR 321.6

GBR 13069 dihydrochloride

B6296-50 50 mg
EUR 1167.6

SKF 91488 dihydrochloride

B6331-10 10 mg
EUR 265.2

SKF 91488 dihydrochloride

B6331-50 50 mg
EUR 926.4

GBR 12783 dihydrochloride

B6332-10 10 mg
EUR 303.6

GBR 12783 dihydrochloride

B6332-50 50 mg
EUR 1082.4

BD 1063 dihydrochloride

B6489-10 10 mg
EUR 205.2
Description: BD 1063 dihydrochloride is an antagonist of ?-1 receptor with Ki value of 9.15 nM [1].?-receptor is a type of opioid receptor. There are two subtypes of ?-receptor: ?-1 and ?-2.?-1 receptor plays an important role in stimulating dopamine release and modulating the actions of cocaine [2].

BD 1063 dihydrochloride

B6489-5 5 mg
EUR 151.2
Description: BD 1063 dihydrochloride is an antagonist of ?-1 receptor with Ki value of 9.15 nM [1].?-receptor is a type of opioid receptor. There are two subtypes of ?-receptor: ?-1 and ?-2.?-1 receptor plays an important role in stimulating dopamine release and modulating the actions of cocaine [2].

RS 16566 dihydrochloride

B6548-10 10 mg
EUR 408

RS 16566 dihydrochloride

B6548-50 50 mg
EUR 1531.2

CGP 20712 dihydrochloride

B6552-10 10 mg
EUR 459.6
Description: CGP 20712 dihydrochloride is a potent and selective antagonist of ?1-adrenoceptor with IC50 value of 0.7 nM [1]. ?1-adrenoceptor is a G-protein coupled receptor and mediates uncoupling protein-1 (UCP1) gene expression induced by norepinephrine (NE) [2].

CGP 20712 dihydrochloride

B6552-50 50 mg
EUR 1746
Description: CGP 20712 dihydrochloride is a potent and selective antagonist of ?1-adrenoceptor with IC50 value of 0.7 nM [1]. ?1-adrenoceptor is a G-protein coupled receptor and mediates uncoupling protein-1 (UCP1) gene expression induced by norepinephrine (NE) [2].

CP 93129 dihydrochloride

B6558-10 10 mg
EUR 381.6

CP 93129 dihydrochloride

B6558-50 50 mg
EUR 1413.6

GR 55562 dihydrochloride

B6572-10 10 mg
EUR 400.8

GR 55562 dihydrochloride

B6572-50 50 mg
EUR 1491.6

RJR 2429 dihydrochloride

B6666-10 10 mg
EUR 369.6

RJR 2429 dihydrochloride

B6666-50 50 mg
EUR 1363.2

SCH 79797 dihydrochloride

B6801-10 10 mg
EUR 285.6

SCH 79797 dihydrochloride

B6801-5 5 mg
EUR 223.2

SKF 86002 dihydrochloride

B6921-10 10 mg
EUR 439.2

SKF 86002 dihydrochloride

B6921-50 50 mg
EUR 1654.8

GW 583340 dihydrochloride

B6989-10 10 mg
EUR 439.2

GW 583340 dihydrochloride

B6989-50 50 mg
EUR 1654.8

CGH 2466 dihydrochloride

B7027-10 10 mg
EUR 340.8
Description: CGH 2466 dihydrochloride is a combined adenosine receptor antagonist. It is an inhibitor of phosphodiesterase type 4 and p38 mitogen-activated protein kinase. It inhibited the phosphodiesterase 4D (PDE4D) isoenzyme with an IC50 value of 22±5 nM.

CGH 2466 dihydrochloride

B7027-50 50 mg
EUR 1245.6
Description: CGH 2466 dihydrochloride is a combined adenosine receptor antagonist. It is an inhibitor of phosphodiesterase type 4 and p38 mitogen-activated protein kinase. It inhibited the phosphodiesterase 4D (PDE4D) isoenzyme with an IC50 value of 22±5 nM.

AZ 12080282 dihydrochloride

A8657-10 10 mg
EUR 498
Description: AZ 12080282 dihydrochloride is a selective inhibitor of Hh with IC50 value <0.012 ?M [1]. It is also reported that AZ 12080282 also has a selective inhibition to p38? with low nanomolar potency [1].

AZ 12080282 dihydrochloride

A8657-50 50 mg
EUR 1900.8
Description: AZ 12080282 dihydrochloride is a selective inhibitor of Hh with IC50 value <0.012 ?M [1]. It is also reported that AZ 12080282 also has a selective inhibition to p38? with low nanomolar potency [1].

AY 9944 dihydrochloride

A8658-10 10 mg
EUR 289.2
Description: AY 9944 dihydrochloride is a selective inhibitor of ?7-sterol reductase with IC50 value of 13 nM [1].?7-sterol reductase (Dhcr7) is an enzyme and plays an important role in catalyzing the production of cholesterol from 7-Dehydrocholesterol through using NADPH [2, 3].

AY 9944 dihydrochloride

A8658-25 25 mg
EUR 582
Description: AY 9944 dihydrochloride is a selective inhibitor of ?7-sterol reductase with IC50 value of 13 nM [1].?7-sterol reductase (Dhcr7) is an enzyme and plays an important role in catalyzing the production of cholesterol from 7-Dehydrocholesterol through using NADPH [2, 3].

AY 9944 dihydrochloride

A8658-5 5 mg
EUR 184.8
Description: AY 9944 dihydrochloride is a selective inhibitor of ?7-sterol reductase with IC50 value of 13 nM [1].?7-sterol reductase (Dhcr7) is an enzyme and plays an important role in catalyzing the production of cholesterol from 7-Dehydrocholesterol through using NADPH [2, 3].

CP 31398 dihydrochloride

A4476-10 10 mg
EUR 381.6
Description: CP 31398 dihydrochloride is a potent activator of p53 with maximum tolerated dose of 400 ppm [2].Tumor protein p53 (p53) is a crucial protein in multicellular organisms and plays an important role in preventing cancer formation.

CP 31398 dihydrochloride

A4476-50 50 mg
EUR 1413.6
Description: CP 31398 dihydrochloride is a potent activator of p53 with maximum tolerated dose of 400 ppm [2].Tumor protein p53 (p53) is a crucial protein in multicellular organisms and plays an important role in preventing cancer formation.

GBR 12783 (dihydrochloride)

HY-100968 5mg
EUR 267.6

GBR 12935 (dihydrochloride)

HY-12242 10mg
EUR 142.8

RN 1 dihydrochloride

B2080-25 each
EUR 705.6

RN 1 dihydrochloride

B2080-5 each
EUR 222

H-9 dihydrochloride

B5001-25 25 mg
EUR 217.2

H-9 dihydrochloride

B5001-50 50 mg
EUR 339.6

RN 1 dihydrochloride

B5784-10 10 mg
EUR 447.6
Description: RN 1 dihydrochloride is a potent and selective inhibitor of LSD1 with IC50 value of 70 nM [1].

RN 1 dihydrochloride

B5784-50 50 mg
EUR 1695.6
Description: RN 1 dihydrochloride is a potent and selective inhibitor of LSD1 with IC50 value of 70 nM [1].

PB 28 dihydrochloride

B7107-10 10 mg
EUR 340.8

PB 28 dihydrochloride

B7107-50 50 mg
EUR 1245.6

H-7 dihydrochloride

B6342-10 10 mg
EUR 188.4

H-7 dihydrochloride

B6342-25 25 mg
EUR 360

H-7 dihydrochloride

B6342-5 5 mg
EUR 134.4

H-7 dihydrochloride

B6342-50 50 mg
EUR 584.4

MM 77 dihydrochloride

B6511-10 10 mg
EUR 340.8

MM 77 dihydrochloride

B6511-50 50 mg
EUR 1245.6

H-7 dihydrochloride

9543-25 each
EUR 652.8

H-7 dihydrochloride

9543-5 each
EUR 210

H-8 dihydrochloride

GK6037-10MG 10 mg
EUR 136.8

In this mini-examination, we discuss such technological achievements offering practical examples of their operability, but also their limits and potential problems that their implementation could increase in clinical microbiology laboratories.

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