Overexpression of LRRC59 Is Associated with Poor Prognosis and Promotes Cell Proliferation and Invasion in Lung Adenocarcinoma

Overexpression of LRRC59 Is Associated with Poor Prognosis and Promotes Cell Proliferation and Invasion in Lung Adenocarcinoma

Objective: LRRC59 (leucine-rich repeat-containing protein 59) is a ribosome-binding protein which also interacts with the fibroblast growth factor. limited investigation reveals the possibility of LRRC59 role in aggressive phenotype of breast cancer. However, if LRRC59 contribute to the development of lung cancer is still unclear.


Materials and Methods: In this study, a software-based survival analysis TCGA online (GEPIA2) was used to estimate the prognostic value LRRC59 mRNA expression levels for lung cancer. Cells Counting Kit-8 assay, colony-forming assay, cell cycle analysis, and transwell test used to assess the biological function LRRC59 in lung cancer cells. Then, 94 lung adenocarcinoma (LUAD) patient tissue were collected to test the level LRRC59 expression by tissue microarray (TMA) based immunohistochemical staining (IHC). Kaplan-Meier univariate and multivariate Cox regression analysis was performed to evaluate the prognostic value of protein expression in LUAD LRRC59.


Results: High Level of LRRC59 mRNA was significantly associated with poorer survival for lung adenocarcinoma, but not for lung squamous cell carcinoma. ShRNA knockdown of LRRC59 by apparently inhibiting cell proliferation and colony formation in both H1299 and A549 cells. G1 / S phase arrest caused by depletion LRRC59 observed in A549 and H1299 cells. In addition, silencing LRRC59 decreased migrative cells and invasive ability. In addition, the TMA-based IHC showed that it was highly expressed in LRRC59 LUAD network and closely associated with lymph node metastasis (P <0.001), TNM stage (P <0.001), and histological differentiation (P = 0.007). Further multivariate analysis showed that excessive LRRC59 an independent prognostic factor in LUAD.


Conclusion: LRRC59 can serve as novel biomarkers and therapeutic targets for clinical practice LUAD.

 Overexpression of LRRC59 Is Associated with Poor Prognosis and Promotes Cell Proliferation and Invasion in Lung Adenocarcinoma
Overexpression of LRRC59 Is Associated with Poor Prognosis and Promotes Cell Proliferation and Invasion in Lung Adenocarcinoma

LncRNA MIR4435-2HG inhibit the progression of osteoarthritis through sponges mir-510-3p

Osteoarthritis (OA) is a joint disorder diarthrodial which can have several causes. Long non-coding RNA (lncRNAs) participated in several diseases, including OA. Recently reported that microRNA lncRNA 4435-2HG (MIR4435-2HG) is downregulated in OA tissue; However, the biological role during the progression of OA MIR4435-2HG still unclear. In this study, interleukin (IL) -1β used to build an in vitro model of OA. protein expression of matrix metallopeptidase (MMP) 1, MMP13, collagen II, interleukin (IL) -17A, p65, phosphorylated (p) -p65, IκB and p-IκB in CHON-001 cells were detected by western blotting.

Gene expression of IL-17A, and miR-510-3p MIR4435-2HG network or CHON-001 cells was measured by reverse transcription-quantitative PCR and western blotting, respectively. Cells Counting Kit-8 assay and immunofluorescence staining were used to investigate cell proliferation, and cell apoptosis was detected by flow cytometry. The relationship between MIR4435-2HG, miR-510-3p and IL-17A was investigated using a dual luciferase assay report. MIR4435-2HG and excess miR-510-3p CHON-transfected into 001 cells.

The results show that excess miR4435-2HG significantly increase proliferation and inhibit apoptosis CHON-001 cells. In addition, miR-510-3p identified as a downstream target MIR4435-2HG, and miR-510-3p directly targeted IL-17A. The results of this study indicate that MIR4435-2HG can mediate the development of OA by disabling NF-kB signaling pathway.

Gelite™ Orange Nucleic Acid Gel Staining Kit

17594 1 Kit
EUR 222

Prosi Silver Staining Kit for 25 mini gel

S3200-020 1kit
EUR 433.2

SafePinky DNA Gel Staining Solution

S1000-050 500ml
EUR 157.2

SafePinky DNA Gel Staining Solution

S1000-100 2X500ml
EUR 225.6

SafePinky DNA Gel Staining Solution

S1000-200 4X500ml
EUR 336

dsGreen Gel Staining Solution, 10000×, 0.5 mL

10010 0.5 mL
EUR 106.8

dsGreen Gel Staining Solution, 10000×, 50 uL

A0010 50 uL
EUR 62.4

Safe E-Red DNA Gel Staining Solution(1000x)

S1002-001 1ml
EUR 133.2

Safe E-Red DNA Gel Staining Solution(1000x)

S1002-005 5x1ml
EUR 271.2

Safe E-Red DNA Gel Staining Solution(1000x)

S1002-010 10ml
EUR 360

Safe E-Red DNA Gel Staining Solution(1000x)

S1002-020 20ml
EUR 595.2

ProLite™ His-Tag Protein Gel Staining Kit *Green Fluorescence*

18010 10 Gels
EUR 412

SafePinky DNA Gel Staining Solution(10,000X) In Water

S1001-025 250ul
EUR 193.2

SafePinky DNA Gel Staining Solution(10,000X) In Water

S1001-050 2x250ul
EUR 296.4

SafePinky DNA Gel Staining Solution(10,000X) In Water

S1001-100 1ml
EUR 522

SafePinky DNA Gel Staining Solution(10,000X) In Water

S1001-500 5x1ml
EUR 1971.6

PI Staining Kit

abx097208-1Kit 1 Kit
EUR 276

DAPI Staining Kit

abx097206-1Kit 1 Kit
EUR 276

Hoechst 33342 Staining Kit

abx097207-1Kit 1 Kit
EUR 276

STAT Double Staining ragent for Double staining Mo

NB330DB 25 ml
EUR 595
Description: STAT Double Staining ragent for Double staining Mouse and Sheep antibodies, 450 Plus slides

?-Galactosidase Staining Kit

AKR-100 1 kit
EUR 518.4
Description: This simple assay measures the transfection efficiency of the LacZ gene using a simple staining protocol.

STAT Double Staining reagent for Double staining o

NB326DB 25 ml
EUR 595
Description: STAT Double Staining reagent for Double staining of Mouse and Rabbit antibodies, 450 plus slides

STAT Double Staining Reagent for Double staining o

NB327DB 25 ml
EUR 595
Description: STAT Double Staining Reagent for Double staining of Mouse and Goat antibodies, 450 plus slides

Dual- Color AP Staining Kit

AP100D-1 100 Assays
EUR 494.4

Red-Color AP Staining Kit

AP100R-1 50 Assays
EUR 314.4

Live/Dead Cell Staining Kit

55R-1434 100 tests
EUR 765.6
Description: Live/Dead Cell Staining Kit for use in the research laboratory

Blue-Color AP Staining Kit

AP100B-1 50 Assays
EUR 203

Lipid (Oil Red O) staining Kit

K580-24 each
EUR 542.4

Live-Dead Cell Staining Kit

K501-100 each
EUR 561.6

Live-Dead Cell Staining Kit

K2081-100 100 staining
EUR 552

Alcian Blue (pH 2.5) Staining Kit

AFR-1 250 ml ea.
EUR 249.6

Alcian Blue (pH 2.5) Staining Kit

AFR-2 30 ml ea.
EUR 153.6

CometAssay Silver Staining Kit

4254-200-K 200 Tests
EUR 390.96

Purple-Color AP Staining Kit

AP100P-1 100 Assays
EUR 235

Nerve Terminal Staining Kit V

70034 1SET
EUR 610.8
Description: Minimum order quantity: 1 unit of 1SET

Beta Galactosidase Staining Kit

55R-1541 250 assays
EUR 444
Description: Assay Kit for detection of Beta Galactosidase in the research laboratory

Red Active Caspase Staining Kit

K2052-100 100 assays
EUR 686.4

Red Active Caspase Staining Kit

K2052-25 25 assays
EUR 285.6

DNA Ploidy Analysis Staining Kit

K1439-1 each
EUR 705.6

DNA Ploidy Analysis Staining Kit

K1439-5 each
EUR 2402.4

Hoechst 33342 / PI Double Staining Kit

abx097209-1Kit 1 Kit
EUR 292.8

Human Histochemistry Staining Kit

20-abx299039
  • EUR 1045.20
  • EUR 1462.80
  • EUR 678.00
  • 150 tests
  • 500 tests
  • 50 tests

Beta-Galactosidase Staining Kit

K802-250 each
EUR 352.8

Alkaline Phosphatase Staining Kit

K2035-50 50 assays
EUR 454.8

Beta-Galactosidase Staining Kit

K2182-250 250 assays
EUR 351.6

Protein Stain-EZ J Phosphoprotein Staining Kit

BSP043 2x10minigel, 20prep
EUR 133.08

Human Type I Collagen Staining Kit

9044 1 kit
EUR 406.26
Description: Human Type I Collagen Staining Kit

Red Active Caspase-3 Staining Kit

K2053-100 100 assays
EUR 686.4

Red Active Caspase-3 Staining Kit

K2053-25 25 assays
EUR 285.6

Red Active Caspase-8 Staining Kit

K2054-100 100 assays
EUR 686.4

Red Active Caspase-8 Staining Kit

K2054-25 25 assays
EUR 285.6

Red Active Caspase-9 Staining Kit

K2055-100 100 assays
EUR 686.4

Red Active Caspase-9 Staining Kit

K2055-25 25 assays
EUR 285.6

Stayright™ Purple HRP Staining Kit

45905 5 mL
EUR 109

Stayright™ Purple HRP Staining Kit

45906 50 mL
EUR 334

CaspGLOW Active Caspase Staining Kit

55R-1292 25 assays
EUR 355.2
Description: Caspase Staining Kit for use activity in the research laboratory

Yeast Viability Staining Kit (Green/Red)

31063-1 1kit
EUR 566.4
Description: Minimum order quantity: 1 unit of 1kit

Stain Tray Slide Staining System

M920-1 1 Clear
EUR 513.6

Stain Tray Slide Staining System

M920-2 1 Black
EUR 534

CaspGLOW Active Caspase 12 Staining Kit

55R-1291 25 assays
EUR 338.4
Description: Caspase 12 Staining Kit for use activity in the research laboratory

CaspGLOW Active Caspase 2 Staining Kit

55R-1293 25 assays
EUR 340.8
Description: Caspase 2 Staining Kit for use activity in the research laboratory

CaspGLOW Active Caspase 3 Staining Kit

55R-1294 25 assays
EUR 355.2
Description: Caspase 3 Staining Kit for use activity in the research laboratory

CaspGLOW Active Caspase 8 Staining Kit

55R-1295 25 assays
EUR 355.2
Description: Caspase 8 Staining Kit for use activity in the research laboratory

CaspGLOW Active Caspase 9 Staining Kit

55R-1296 25 assays
EUR 355.2
Description: Caspase 9 Staining Kit for use activity in the research laboratory

Fluorescein Active Caspase Staining Kit

K2047-100 100 assays
EUR 686.4

Fluorescein Active Caspase Staining Kit

K2047-25 25 assays
EUR 285.6

CaspGLOW Red Active Caspase Staining Kit

55R-1297 25 assays
EUR 355.2
Description: Caspase Staining Kit for use activity in the research laboratory

CaspGLOW? Red Active Caspase Staining Kit

K190-100 each
EUR 627.6

CaspGLOW? Red Active Caspase Staining Kit

K190-25 each
EUR 288

STAT-Q Goat AEC KIT for staining all Goat primary

NB314KLGC-20 20 ml kit
EUR 589
Description: STAT-Q Goat AEC KIT for staining all Goat primary antibodies, 350 plus slides

STAT-Q Goat DAB KIT for staining all Goat primary

NB314KLGD-20 20 ml kit
EUR 589
Description: STAT-Q Goat DAB KIT for staining all Goat primary antibodies, 350 plus slides

STAT-Q Rabbit AEC KIT for staining all Rabbit anti

NB314KLRC-20 20 ml kit
EUR 589
Description: STAT-Q Rabbit AEC KIT for staining all Rabbit antibodies, 350 plus slides

STAT-Q Rabbit DAB KIT for staining all Rabbit anti

NB314KLRD-20 20 ml kit
EUR 585
Description: STAT-Q Rabbit DAB KIT for staining all Rabbit antibodies, 350 plus slides

PI / RNase Staining Buffer

20-abx090619
  • EUR 326.40
  • EUR 276.00
  • 100 tests
  • 50 tests

CaspGLOW Red Active Caspase 3 Staining Kit

55R-1298 25 assays
EUR 355.2
Description: Caspase 3 Staining Kit for use activity in the research laboratory

CaspGLOW Red Active Caspase 8 Staining Kit

55R-1299 25 assays
EUR 355.2
Description: Caspase 8 Staining Kit for use activity in the research laboratory

CaspGLOW Red Active Caspase 9 Staining Kit

55R-1300 25 assays
EUR 355.2
Description: Caspase 9 Staining Kit for use activity in the research laboratory

Sirius Red/Fast Green Collagen Staining Kit

9046 30-50 samples
EUR 164.4
Description: Sirius Red/Fast Green Collagen Staining Kit

Fluorescein Active Caspase-2 Staining Kit

K2048-100 100 assays
EUR 686.4

Fluorescein Active Caspase-2 Staining Kit

K2048-25 25 assays
EUR 285.6

Fluorescein Active Caspase-3 Staining Kit

K2049-100 100 assays
EUR 686.4

Fluorescein Active Caspase-3 Staining Kit

K2049-25 25 assays
EUR 285.6

Fluorescein Active Caspase-8 Staining Kit

K2050-100 100 assays
EUR 686.4

Fluorescein Active Caspase-8 Staining Kit

K2050-25 25 assays
EUR 285.6

Fluorescein Active Caspase-9 Staining Kit

K2051-100 100 assays
EUR 686.4

Fluorescein Active Caspase-9 Staining Kit

K2051-25 25 assays
EUR 285.6

Stains-All

D6359 1g
EUR 126.82

Stains-All

HY-D0987 200mg
EUR 129.6

Live-or-Dye NuCFix Red Staining Kit (200 assays)

32010 1kit
EUR 326.4
Description: Minimum order quantity: 1 unit of 1kit

CaspGLOW? Red Active Caspase-3 Staining Kit

K193-100 each
EUR 639.6

CaspGLOW? Red Active Caspase-3 Staining Kit

K193-25 each
EUR 288

CaspGLOW? Red Active Caspase-9 Staining Kit

K199-100 each
EUR 620.4

CaspGLOW? Red Active Caspase-9 Staining Kit

K199-25 each
EUR 288

CaspGLOW? Red Active Caspase-8 Staining Kit

K198-100 each
EUR 627.6

CaspGLOW? Red Active Caspase-8 Staining Kit

K198-25 each
EUR 288

Fluorescein Active Caspase-12 Staining Kit

K2046-100 100 assays
EUR 686.4

Fluorescein Active Caspase-12 Staining Kit

K2046-25 25 assays
EUR 285.6

Type IX Collagen Staining Kit, Multi-Species

9012 1 kit
EUR 406.26
Description: Type IX Collagen Staining Kit

Blue Feulgen DNA Ploidy Analysis Staining Kit

DPK500 1 kit(s)
EUR 427.2

PAP PEN FOR IMMUNO STAINING

Z377821-1EA EACH
EUR 171.03

Staining Jar PP + Lid 10 Slide

MIC6002 EACH
EUR 67.2

StemTAG Alkaline Phosphatase Staining Kit (Red)

CBA-300 100 assays
EUR 553.2
Description: Alkaline Phosphatase (AP) is a widely used marker for both mouse and human embryonic stem cells (ES) and embryonic germ cells (EG). Our StemTAG Alkaline Phosphatase kits provide an efficient system for monitoring cell differentiation or undifferentiation using the AP marker. The StemTAG Alkaline Phosphatase Staining Kits provide reagents for monitoring alkaline phosphatase activity via immunocytochemistry staining.

Human FoxP3 Transcription Factor Staining Kit

OKTA00001 KIT
EUR 544.8
Description: Description of target: ;Species reactivity: ;Application: FC;Assay info: ;Sensitivity:

Human FoxP3 Transcription Factor Staining Kit

OKTA00004 KIT
EUR 544.8
Description: Description of target: ;Species reactivity: ;Application: FC;Assay info: ;Sensitivity:

Genorise® Alkaline Phosphatase Staining Kit

GR107045 100 tests
EUR 289

Ponceau S Staining Solution

B7778-100000 100 g
EUR 195.6

Ponceau S Staining Solution

B7778-50000 50 g
EUR 151.2

SDS-PAGE Staining Solution

GR103068 100 mL
EUR 58

Ponceau S Staining Solution

PW005 100ml
EUR 82.97

Cell Navigator® Live Cell Tubulin Staining Kit

23170 100 Slides
EUR 222

Cell Navigator® Live Cell Tubulin Staining Kit

23171 300 Slides
EUR 446

Wheaton staining dishes 3 EA

S5017-3EA PK3
EUR 135.6

EasyDip Slide Staining System

M900-12AS-ASSORTED 1 Case(s)
EUR 211.2

StemTAG Alkaline Phosphatase Staining Kit (Purple)

CBA-306 100 assays
EUR 553.2
Description: Alkaline Phosphatase (AP) is a widely used marker for both mouse and human embryonic stem cells (ES) and embryonic germ cells (EG). Our StemTAG Alkaline Phosphatase kits provide an efficient system for monitoring cell differentiation or undifferentiation using the AP marker. The StemTAG Alkaline Phosphatase Staining Kits provide reagents for monitoring alkaline phosphatase activity via immunocytochemistry staining.

CaspGLOW? Fluorescein Active Caspase Staining Kit

K180-100 each
EUR 660

CaspGLOW? Fluorescein Active Caspase Staining Kit

K180-25 each
EUR 280.8

Nalgene Box Staining 13x13x5cm

BOX1040 EACH
EUR 48

Staining Jar W Lid 115x115x77mm

MIC6016 PK10
EUR 428.4

Manual Staining System (12 Wells)

IMS001 1 ea.
EUR 427.2

CaspGLOW™ Green Active Caspase-3/7 Staining Kit

K2030-25 25 assays
EUR 272.4

Disposable Slide Staining Trays

MIC5070 PK4
EUR 90

Staining Trough+Lid Rectangular

MIC6008 EACH
EUR 27.6

EZCell? Intracellular Zinc Staining Kit (Cell-Based)

K525-50 each
EUR 679.2

Staining Dish with Cover Plastic

X24085 EACH
EUR 156

OxiSelect DNA Double-Strand Break (DSB) Staining Kit

STA-321 100 assays
EUR 790.8
Description: Double-strand breaks (DSB) in DNA are among the most dangerous types of DNA damage occuring within cells. One of the earliest cellular responses to double-strand breaks is the phosphorylation of a histone variant, H2AX, at the sites of DNA damage. Within seconds Ser139 is phosphorylated when DSBs are induced in mammalian cells. Phosphorylation of this serine residue causes chromatin condensation and appears to play a critical role in the recruitment of repair or damage-signaling factors to the DNA damage sites. The OxiSelect DNA Double-Strand Break Staining Kit provides an easy-to-use method for detecting the presence of DSBs in cells cultured in microtiter plates. Double strand breaks can be detected in just a few hours by immunofluorescence staining of the phosphorylated histone H2AX.

CaspGLOW? Fluorescein Active Caspase-3 Staining Kit

K183-100 each
EUR 660

CaspGLOW? Fluorescein Active Caspase-3 Staining Kit

K183-25 each
EUR 280.8

CaspGLOW? Fluorescein Active Caspase-2 Staining Kit

K182-100 each
EUR 627.6

CaspGLOW? Fluorescein Active Caspase-2 Staining Kit

K182-25 each
EUR 280.8

CaspGLOW? Fluorescein Active Caspase-9 Staining Kit

K189-100 each
EUR 660

CaspGLOW? Fluorescein Active Caspase-9 Staining Kit

K189-25 each
EUR 288

CaspGLOW? Fluorescein Active Caspase-8 Staining Kit

K188-100 each
EUR 660

CaspGLOW? Fluorescein Active Caspase-8 Staining Kit

K188-25 each
EUR 288

7-AAD Viability Staining Buffer

abx090617-100tests 100 tests
EUR 260.4

Simport EasyDip Staining Jar Blue

HIS0273 PK6
EUR 117.6

Simport EasyDip Staining Jar Pink

HIS0275 PK6
EUR 117.6

Mouse to Mouse HRP Staining System

MTM003 400 Slides
EUR 433.2

Lysosomal Cytotoxicity Dual Staining Kit (Cell-Based)

K458-50 each
EUR 686.4

Autophagy/Cytotoxicity Dual Staining Kit (Cell-Based)

K449-50 each
EUR 652.8

CaspGLOW? Fluorescein Active Caspase-12 Staining Kit

K172-100 each
EUR 627.6

CaspGLOW? Fluorescein Active Caspase-12 Staining Kit

K172-25 each
EUR 280.8

Simport EasyDip Staining Jar Green

HIS0274 PK6
EUR 117.6

Simport EasyDip Staining Jar White

HIS0276 PK6
EUR 110.4

Simport EasyDip Staining Rack Grey

HIS0278 PK6
EUR 128.4

BRAND(TM) STAINING TRAY FOR 25 SLIDES

BR471400-5EA PK5
EUR 58.1

BRAND(TM) STAINING TRAY FOR 20 SLIDES

BR474305-2EA PK2
EUR 43.2

Live-or-Dye UV/448 Fixable Viability Staining Kit (200 assays)

32002 1kit
EUR 339.6
Description: Minimum order quantity: 1 unit of 1kit

Live-or-Dye 405/452 Fixable Viability Staining Kit (200 assays)

32003 1kit
EUR 339.6
Description: Minimum order quantity: 1 unit of 1kit

Live-or-Dye 488/515 Fixable Viability Staining Kit (200 assays)

32004 1kit
EUR 339.6
Description: Minimum order quantity: 1 unit of 1kit

Live-or-Dye 568/583 Fixable Viability Staining Kit (200 assays)

32005 1kit
EUR 339.6
Description: Minimum order quantity: 1 unit of 1kit

Live-or-Dye 594/614 Fixable Viability Staining Kit (200 assays)

32006 1kit
EUR 339.6
Description: Minimum order quantity: 1 unit of 1kit

Live-or-Dye 640/662 Fixable Viability Staining Kit (200 assays)

32007 1kit
EUR 339.6
Description: Minimum order quantity: 1 unit of 1kit

Live-or-Dye 750/777 Fixable Viability Staining Kit (200 assays)

32008 1kit
EUR 339.6
Description: Minimum order quantity: 1 unit of 1kit

Live-or-Dye 405/545 Fixable Viability Staining Kit (200 assays)

32009 1kit
EUR 339.6
Description: Minimum order quantity: 1 unit of 1kit

7-AAD Viability Staining Solution

EXB0026 400 tests
EUR 91.2

Simport EasyDip Staining Jar Yellow

HIS0277 PK6
EUR 110.4

Hellandahl Staining Jar+Lid 16 slide

MIC6004 EACH
EUR 34.8

MemBriteâ„¢ Fix-ST 650/665 Cell Surface Staining Kit, 500 Reactions

30101 1KIT
EUR 772.8
Description: Minimum order quantity: 1 unit of 1KIT

MemBriteâ„¢ Fix-ST 650/665 Cell Surface Staining Kit, 100 Reactions

30101-T 1KIT
EUR 266.4
Description: Minimum order quantity: 1 unit of 1KIT

MemBriteâ„¢ Fix-ST 667/685 Cell Surface Staining Kit, 500 Reactions

30102 1KIT
EUR 772.8
Description: Minimum order quantity: 1 unit of 1KIT

MemBriteâ„¢ Fix-ST 667/685 Cell Surface Staining Kit, 100 Reactions

30102-T 1KIT
EUR 266.4
Description: Minimum order quantity: 1 unit of 1KIT

MemBriteâ„¢ Fix-ST 681/698 Cell Surface Staining Kit, 500 Reactions

30103 1KIT
EUR 772.8
Description: Minimum order quantity: 1 unit of 1KIT

MemBriteâ„¢ Fix-ST 681/698 Cell Surface Staining Kit, 100 Reactions

30103-T 1KIT
EUR 266.4
Description: Minimum order quantity: 1 unit of 1KIT

MemBriteâ„¢ Fix-ST 755/777 Cell Surface Staining Kit, 500 Reactions

30104 1KIT
EUR 772.8
Description: Minimum order quantity: 1 unit of 1KIT

MemBriteâ„¢ Fix-ST 755/777 Cell Surface Staining Kit, 100 Reactions

30104-T 1KIT
EUR 266.4
Description: Minimum order quantity: 1 unit of 1KIT

Cell Navigator® Lysosome Staining Kit *NIR Fluorescence*

22652 500 Tests
EUR 222

Cell Navigator® Lysosome Staining Kit *Red Fluorescence*

22658 500 Tests
EUR 166

STAT-Q Mouse Adsorbed AEC KIT for staining Rat an

NB314MAK-AEC 200-250 slide kit
EUR 695
Description: STAT-Q Mouse Adsorbed AEC KIT for staining Rat antibodies-on-Mouse tissues 250 plus slide kit

Mouse to Mouse HRP (DAB) Staining System

MTM001 70 Slides
EUR 188.4

Mouse to Mouse HRP (AEC) Staining System

MTM002 70 Slides
EUR 188.4

Live-or-Dye NuCFix Red Staining Kit, Trial Size (50 assays)

32010-T 1kit
EUR 139.2
Description: Minimum order quantity: 1 unit of 1kit

Coplin Staining Jar Glass+Lid 10Slide

MIC6000 EACH
EUR 13.2

Cell Navigator® Lysosome Staining Kit *Blue Fluorescence*

22655 500 Tests
EUR 166

STAT-Q Mouse Adsorbed DAB KIT for staining Rat ant

NB314MAK-DAB 200-250 slides
EUR 695
Description: STAT-Q Mouse Adsorbed DAB KIT for staining Rat antibodies-on-Mouse tissues 250 plus slide kit

STAT-Q Rat Adsorbed AEC KIT for staining Mouse ant

NB314RAK-AEC 200-250 slide kit
EUR 695
Description: STAT-Q Rat Adsorbed AEC KIT for staining Mouse antibodies-on-Rat tissues 250 plus slides kit

STAT-Q Rat Adsorbed DAB KIT for staining Mouse ant

NB314RAK-DAB 200-250 slides
EUR 695
Description: STAT-Q Rat Adsorbed DAB KIT for staining Mouse antibodies-on-Rat tissues 250 plus slides kit

Coomassie Blue Fast Staining Solution

AR0170 100mL(for 10 assays to stain gels of 5 x 8.5cm)
EUR 96

Staining Jar Schiefferdecker With Lid

MIC6014 EACH
EUR 22.8

STAT-Q Multivalent AEC KIT for staining Mouse, Rat

NB314KLC 1000 slide kit
EUR 875
Description: STAT-Q Multivalent AEC KIT for staining Mouse, Rat and Rabbit antibodies, 1000 plus slides (Large size kit)

STAT-Q Multivalent AEC KIT for staining Mouse, Rat

NB314KLC-20 300 slides
EUR 595
Description: STAT-Q Multivalent AEC KIT for staining Mouse, Rat and Rabbit antibodies, 350 plus slides (Small size kit)

STAT-Q Multivalent DAB KIT for staining Mouse, Rat

NB314KLD 1000 slides
EUR 895
Description: STAT-Q Multivalent DAB KIT for staining Mouse, Rat and Rabbit antibodies, 1000 plus slides (Large size kit)

STAT-Q Multivalent DAB KIT for staining Mouse, Rat

NB314KLD-20 300 slide kit
EUR 595
Description: STAT-Q Multivalent DAB KIT for staining Mouse, Rat and Rabbit antibodies, 350 slides kit (Small size Kit)

Cell Navigator® Lysosome Staining Kit *Green Fluorescence*

22656 500 Tests
EUR 166

Vertical Slide Staining Rack Dark Gray

M905-12DGY 1 Case(s)
EUR 220.8

OxiSelect Cellular UV-Induced DNA Damage Staining Kit (CPD)

STA-327 96 assays
EUR 790.8
Description: Our OxiSelect Cellular UV-Induced DNA Damage Staining Kit measures the formation of cyclobutane pyrimidine dimers (CPD) by immunofluorescence. Cells are first seeded in a 96-well tissue culture plate. Wells are then UV irradiated to induce DNA damage. After fixation and denaturation, cells containing the DNA lesions are probed with an anti-CPD antibody, followed by a FITC conjugated secondary antibody. The unbound secondary antibody is removed during a wash step, and stained cells can then be visualized with a fluorescence microscope.

Cellular Senescence Detection Kit (SA-?-Gal Staining)

CBA-230 50 assays
EUR 622.8
Description: Our Cellular Senescence Staining Kit provides an efficient method to visualize Senescence Associated (SA) ß-galactosidase. SA-ß-Gal catalyzes the hydrolysis of X-gal, which produces a blue color in senescent cells. Visualize results with a standard light microscope.

Cellular Senescence Detection Kit (SA-?-Gal Staining)

CBA-230-5 5 x 50 assays
EUR 2461.2
Description: Our Cellular Senescence Staining Kit provides an efficient method to visualize Senescence Associated (SA) ß-galactosidase. SA-ß-Gal catalyzes the hydrolysis of X-gal, which produces a blue color in senescent cells. Visualize results with a standard light microscope.

Cell Navigator® Lysosome Staining Kit *Orange Fluorescence*

22657 500 Tests
EUR 166

OxiSelect DNA Double Strand Break (DSB) Staining Kit, Trial Size

STA-321-T 20 assays
EUR 421.2
Description: Double-strand breaks (DSB) in DNA are among the most dangerous types of DNA damage occuring within cells. One of the earliest cellular responses to double-strand breaks is the phosphorylation of a histone variant, H2AX, at the sites of DNA damage. Within seconds Ser139 is phosphorylated when DSBs are induced in mammalian cells. Phosphorylation of this serine residue causes chromatin condensation and appears to play a critical role in the recruitment of repair or damage-signaling factors to the DNA damage sites. The OxiSelect DNA Double-Strand Break Staining Kit provides an easy-to-use method for detecting the presence of DSBs in cells cultured in microtiter plates. Double strand breaks can be detected in just a few hours by immunofluorescence staining of the phosphorylated histone H2AX.

Staining Jar 4ml Cavity 40x40mm With lid

MIC6006 EACH
EUR 8.4

In addition, excess miR4435-2HG inhibit the development of OA, indicating that miR4435-2HG can be considered as a potential therapeutic target in OA.

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