Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux

Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux

Background: Cerebral ischemia-reperfusion (I / R) injury can cause severe dysfunction, and treatment difficult. It is reported that the nucleotide-binding domain and a leucine-rich repeat protein family of 3 (NLRP3) inflammasome-mediated cell pyroptosis an important part of the I / R injury of the brain and can inhibit the activation of autophagy pyroptosis in some tissue injury. Our previous research found that the protective effect of bone marrow mesenchymal stem cells (BMSCs) in brain I / R injury may be associated with the regulation of autophagy.

Recent research has shown that exosomes secreted from BMSCs (BMSC-Exos) may play an important role in effective biological performance BMSCs and BMSC-Exos protective mechanism associated with the activation of autophagy and remission of inflammation, but have not been reported in studies of injury I / R brain. We aimed to investigate the effects of BMSC-Exos on I / R injury of the brain and determine whether the mechanisms associated with the regulation pyroptosis and autophagic flux.

Methods: PC12 cells were subjected to a shortage of oxygen-glucose / reoxygenation (OGD / R) to induce brain I / R in vitro and cocultured with BMSC-Exos. cell viability was determined by CCK-8 kit and lactate dehydrogenase (LDH) detection. Scanning electron microscopy (SEM), Hoechst 33 342 / propidium iodide (PI) double staining, 2 ‘, 7’-dichlorodihydrofluorescein diacetate assay, immunofluorescence, Western blot and enzyme-linked immunosorbent assay (ELISA) was used to detect cell pyroptosis. Furthermore, transmission electron microscopy (TEM), GFP-RFP-LC3 adenovirus transfection, and Western blot used to detect autophagic flux and its influence on pyroptosis.

Finally, coimmunoprecipitation used to detect the binding interaction between NLRP3 and LC3. Results: BMSC-Exos increased cell viability in OGD / R inhibitory effect of BMSC-Exos on pyroptosis is comparable to NLRP3 inhibitor NLRP3 MCC950 and reversed by excess. Furthermore, BMSC-Exos promoted autophagic flux through AMP-activated kinase (AMPK) / mammalian target of rapamycin on the track, whereas chloroquine, AMPK silencing, and compound C block the inhibitory effects on pyroptosis. Conclusion: BMSC-Exos can protect PC12 cells against injury OGD / R by the weakening of the NLRP3 inflammasome-mediated pyroptosis to promote the AMPK-dependent autophagic flux.

 Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux
Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux

Effect of Morinda citrifolia (Noni) on Cell Viability of Stem Cells and Osteogenesis spheroids

Background and purpose: Morinda citrifolia (Noni) has been widely used in herbal medicine to treat and prevent various diseases. We undertook this study to evaluate the effects of Noni extract on morphology maintenance, increase cellular viability, and improved osteogenesis of stem cell spheroids.

Materials and Methods: We cultured stem cell spheroids made with gingival-derived stem cells in the presence of Noni extract at concentrations of 10, 100 and 200 ng / mL. We do the analysis of changes in cell morphology and cell viability. We did a test alkaline phosphatase activity using a kit and test the mineralization using anthraquinone dye to evaluate osteogenesis of stem cell spheroids with the addition of Noni extract.

Scienceware Coplin staining jar with screw cap

S5641-12EA PK12
EUR 113.54

?-Galactosidase Staining Kit

AKR-100 1 kit
EUR 518.4
Description: This simple assay measures the transfection efficiency of the LacZ gene using a simple staining protocol.

DAPI Staining Kit

abx097206-1Kit 1 Kit
EUR 276

PI Staining Kit

abx097208-1Kit 1 Kit
EUR 276

Sheep TRAP ELISA Kit

EST0544 96Tests
EUR 625.2

Human TRAP ELISA Kit

EHT0544 96Tests
EUR 625.2

Porcine TRAP ELISA Kit

EPT0544 96Tests
EUR 625.2

Monkey TRAP ELISA Kit

EMKT0544 96Tests
EUR 625.2

Mouse TRAP ELISA Kit

EMT0544 96Tests
EUR 625.2

Rat TRAP ELISA Kit

ERT0544 96Tests
EUR 625.2

Goat TRAP ELISA Kit

EGTT0544 96Tests
EUR 625.2

Bovine TRAP ELISA Kit

EBT0544 96Tests
EUR 625.2

Mouse TRAP ELISA Kit

ELI-03023m 96 Tests
EUR 1038

Chicken TRAP ELISA Kit

ECKT0544 96Tests
EUR 625.2

Canine TRAP ELISA Kit

ECT0544 96Tests
EUR 625.2

TRAP-6

A8675-5 5 mg
EUR 207.6
Description: Peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. Stimulates platelet aggregation (EC50 = 0.8 ?M), promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation

TRAP Antibody

6911-002mg 0.02 mg
EUR 206.18
Description: TRAP Antibody: TRAP, also known as uteroferrin, is an iron containing, glycosylated, acid phosphatase. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. Along with the related protein ACP2, TRAP mediates the removal of mannose 6-phosphate residues from proteins targeted to lysosomes. TRAP is present in brain at low levels, but is expressed at a much higher level in liver.

TRAP Antibody

6911-01mg 0.1 mg
EUR 523.7
Description: TRAP Antibody: TRAP, also known as uteroferrin, is an iron containing, glycosylated, acid phosphatase. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. Along with the related protein ACP2, TRAP mediates the removal of mannose 6-phosphate residues from proteins targeted to lysosomes. TRAP is present in brain at low levels, but is expressed at a much higher level in liver.

TRAP Peptide

6911P 0.05 mg
EUR 197.7
Description: (CT) TRAP peptide

TRAP-14

5-02017 4 x 5mg Ask for price

TRAP antibody

70R-12535 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal TRAP antibody

TRAP antibody

22406-100ul 100ul
EUR 468

TRAP Antibody

25505-100ul 100ul
EUR 468

TRAP -6

ABP-TRA-1 5,0mg vial
EUR 204

Trap 101

B7084-10 10 mg
EUR 447.6

Trap 101

B7084-50 50 mg
EUR 1635.6

TRAP-6

HY-P0078 10mM/1mL
EUR 386.4

TRAP-6

H-7764.0500 0.5mg
EUR 57.6
Description: Sum Formula: C34H56N10O9; CAS# [141136-83-6] net

TRAP-6

H-7764.1000 1.0mg
EUR 72
Description: Sum Formula: C34H56N10O9; CAS# [141136-83-6] net

TRAP-14

H-8105.0001 1.0mg
EUR 181.2
Description: Sum Formula: C81H118N20O23; CAS# [137339-65-2] net

TRAP-14

H-8105.0005 5.0mg
EUR 618
Description: Sum Formula: C81H118N20O23; CAS# [137339-65-2] net

TRAP-6

H-8365.0005 5.0mg
EUR 327.6
Description: Sum Formula: C34H56N10O9; CAS# [141136-83-6] net

TRAP-6

H-8365.0025 25.0mg
EUR 1197.6
Description: Sum Formula: C34H56N10O9; CAS# [141136-83-6] net

TRAP-7

H-2234.0005 5.0mg
EUR 646.8
Description: Sum Formula: C39H63N11O10; CAS# [145229-76-1] net

TRAP-7

H-2234.0025 25.0mg
EUR 2473.2
Description: Sum Formula: C39H63N11O10; CAS# [145229-76-1] net

TRAP-5

H-1408.0005 5.0mg
EUR 691.2
Description: Sum Formula: C30H50N8O7; CAS# [141685-53-2] net

TRAP-5

H-1408.0025 25.0mg
EUR 2648.4
Description: Sum Formula: C30H50N8O7; CAS# [141685-53-2] net

Rat(TRAP)

QY-E11743 96T
EUR 448.8

Beta Galactosidase Staining Kit

55R-1541 250 assays
EUR 444
Description: Assay Kit for detection of Beta Galactosidase in the research laboratory

CometAssay Silver Staining Kit

4254-200-K 200 Tests
EUR 390.96

Hoechst 33342 Staining Kit

abx097207-1Kit 1 Kit
EUR 276

Human Histochemistry Staining Kit

20-abx299039
  • EUR 1045.20
  • EUR 1462.80
  • EUR 678.00
  • 150 tests
  • 500 tests
  • 50 tests

Beta-Galactosidase Staining Kit

K802-250
EUR 352.8

Alkaline Phosphatase Staining Kit

K2035-50 50 assays
EUR 454.8

Beta-Galactosidase Staining Kit

K2182-250 250 assays
EUR 351.6

Guinea Pig TRAP ELISA Kit

EGT0544 96Tests
EUR 625.2

AAVS1 Safe Harbor Targeting Vector 2.0 - All-Purpose Donor (AAVS1-SA-puro-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)

GE620A-KIT 1 kit
EUR 2558.4

Cell Navigator™ Mitochondrion Staining Kit *Orange Fluorescence with 405 nm Excitation*

22673 500 Assays
EUR 262.8

Cell Navigator™ Lysosome Staining Kit *Green Fluorescence with 405 nm Excitation*

22651 500 Tests
EUR 262.8

TRAP Conjugated Antibody

C44711 100ul
EUR 476.4

TRAP Conjugated Antibody

C36331 100ul
EUR 476.4

TRAP Conjugated Antibody

C38129 100ul
EUR 476.4

[Cit5]-TRAP-5

5-00062 4 x 5mg Ask for price

[Tyr1]-TRAP-7

5-00339 4 x 5mg Ask for price

Scrambled TRAP Fragment

5-01910 4 x 5mg Ask for price

TRAP-14 amide

5-02018 4 x 1mg Ask for price

TRAP-5 amide

5-02019 4 x 5mg Ask for price

TRAP-14 Peptide

20-abx266463
  • EUR 661.20
  • EUR 1111.20
  • EUR 477.60
  • 10 mg
  • 25 mg
  • 5 mg

Polyclonal TRAP Antibody

APR10538G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TRAP . This antibody is tested and proven to work in the following applications:

TRAP-14 amide

H-6032.0001 1.0mg
EUR 254.4
Description: Sum Formula: C81H119N21O22; CAS# [141923-36-6] net

TRAP-14 amide

H-6032.0005 5.0mg
EUR 907.2
Description: Sum Formula: C81H119N21O22; CAS# [141923-36-6] net

TRAP-6 amide

H-2936.0005 5.0mg
EUR 138
Description: Sum Formula: C34H57N11O8; CAS# [141923-40-2] net

TRAP-6 amide

H-2936.0025 25.0mg
EUR 441.6
Description: Sum Formula: C34H57N11O8; CAS# [141923-40-2] net

TRAP-5 amide

H-2938.0025 25.0mg
EUR 646.8
Description: Sum Formula: C30H51N9O6; CAS# [141923-41-3] net

TRAP-5 amide

H-2938.0100 100.0mg
EUR 1864.8
Description: Sum Formula: C30H51N9O6; CAS# [141923-41-3] net

(Tyr1)-TRAP-7

H-1674.0001 1.0mg
EUR 151.2
Description: Sum Formula: C45H67N11O10; CAS# [149440-16-4] net

(Tyr1)-TRAP-7

H-1674.0005 5.0mg
EUR 501.6
Description: Sum Formula: C45H67N11O10; CAS# [149440-16-4] net

CD40 Ligand/TRAP

PR29002 50 ug
EUR 589.2

Anti-TRAP antibody

STJ190098 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to TRAP (2H2)

anti-TRAP alpha

YF-PA14790 50 ul
EUR 435.6
Description: Mouse polyclonal to TRAP alpha

anti-TRAP alpha

YF-PA14791 50 ug
EUR 435.6
Description: Mouse polyclonal to TRAP alpha

Gst Spin Trap

28952359 PK50
EUR 448.02

TRAP Antibody (CD40L)

F49677-0.08ML 0.08 ml
EUR 165

TRAP Antibody (CD40L)

F49677-0.4ML 0.4 ml
EUR 379

AAVS1 Safe Harbor Targeting Vector 2.0 - GOI Knock-in Donor (AAVS1-SA-puro-EF1-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)

GE622A-KIT 1 kit
EUR 2558.4

AAVS1 Safe Harbor Targeting Vector 2.0 - Reporter Knock-in Donor (AAVS1-SA-puro-MCS-GFP), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)

GE624A-KIT 1 kit
EUR 2558.4

ExoAb Antibody Kit (CD9, CD63, CD81, Hsp70 antibodies, rabbit anti-human) with goat anti-rabbit HRP secondary antibody

EXOAB-KIT-1 25 ul each
EUR 752.4

Frit Kit

FRIT-KIT 1each
EUR 148.8
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

CaspGLOW Active Caspase Staining Kit

55R-1292 25 assays
EUR 355.2
Description: Caspase Staining Kit for use activity in the research laboratory

Live/Dead Cell Staining Kit

55R-1434 100 tests
EUR 765.6
Description: Live/Dead Cell Staining Kit for use in the research laboratory

Nerve Terminal Staining Kit V

70034 1SET
EUR 610.8
Description: Minimum order quantity: 1 unit of 1SET

Blue-Color AP Staining Kit

AP100B-1 50 Assays
EUR 314.4

Dual- Color AP Staining Kit

AP100D-1 100 Assays
EUR 494.4

Red-Color AP Staining Kit

AP100R-1 50 Assays
EUR 314.4

DNA Ploidy Analysis Staining Kit

K1439-1
EUR 705.6

DNA Ploidy Analysis Staining Kit

K1439-5
EUR 2402.4

Live-Dead Cell Staining Kit

K501-100
EUR 561.6

Fluorescein Active Caspase Staining Kit

K2047-100 100 assays
EUR 686.4

Fluorescein Active Caspase Staining Kit

K2047-25 25 assays
EUR 285.6

Red Active Caspase Staining Kit

K2052-100 100 assays
EUR 686.4

Red Active Caspase Staining Kit

K2052-25 25 assays
EUR 285.6

Live-Dead Cell Staining Kit

K2081-100 100 staining
EUR 552

Column Packing Kit

PACK-KIT 1pack
EUR 1242
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

PCR Mycoplasma Detection Kit

M034-Kit Kit
EUR 319.2

[Phe1, Ser2]-TRAP-6

5-00263 4 x 5mg Ask for price

TRAP-6 (2-6)

5-02020 4 x 5mg Ask for price

CD40Ligand/TRAP, human recombinant

4014-10
EUR 164.4

CD40Ligand/TRAP, human recombinant

4014-1000
EUR 1951.2

CD40Ligand/TRAP, human recombinant

4014-50
EUR 307.2

CD40Ligand/TRAP, murine recombinant

4015-100
EUR 770.4

CD40Ligand/TRAP, murine recombinant

4015-1000
EUR 3778.8

CD40Ligand/TRAP, murine recombinant

4015-25
EUR 294

CD40Ligand/TRAP, murine recombinant

4015-500
EUR 2343.6

TRAP-5 amide Peptide

20-abx265852
  • EUR 427.20
  • EUR 644.40
  • EUR 343.20
  • 10 mg
  • 25 mg
  • 5 mg

Scrambled TRAP Fragment Peptide

20-abx265858
  • EUR 427.20
  • EUR 644.40
  • EUR 343.20
  • 10 mg
  • 25 mg
  • 5 mg

[Tyr1]-TRAP-7 Peptide

20-abx265889
  • EUR 427.20
  • EUR 644.40
  • EUR 343.20
  • 10 mg
  • 25 mg
  • 5 mg

[Cit5]-TRAP-5 Peptide

20-abx265945
  • EUR 460.80
  • EUR 710.40
  • EUR 360.00
  • 10 mg
  • 25 mg
  • 5 mg

Anti-TRAP Monoclonal Antibody

M03277-1 100ug
EUR 476.4
Description: Rabbit Monoclonal TRAP Antibody. Validated in IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

ACP5/TRAP, human recombinant

P1055-10
EUR 196.8

ACP5/TRAP, human recombinant

P1055-50
EUR 705.6

(Phe1,Ser2)-TRAP-6

H-5996.0005 5.0mg
EUR 356.4
Description: Sum Formula: C34H56N10O9; CAS# [374898-11-0] net

(Phe1,Ser2)-TRAP-6

H-5996.0025 25.0mg
EUR 1311.6
Description: Sum Formula: C34H56N10O9; CAS# [374898-11-0] net

TRAP-6 (2-6)

H-8325.0005 5.0mg
EUR 327.6
Description: Sum Formula: C31H51N9O7; CAS# [141136-84-7] net

TRAP-6 (2-6)

H-8325.0025 25.0mg
EUR 1197.6
Description: Sum Formula: C31H51N9O7; CAS# [141136-84-7] net

(DL-Isoser1)-TRAP-6

H-1944.0001 1.0mg
EUR 327.6
Description: Sum Formula: C34H56N10O9; CAS# [150242-29-8] net

(DL-Isoser1)-TRAP-6

H-1944.0005 5.0mg
EUR 1197.6
Description: Sum Formula: C34H56N10O9; CAS# [150242-29-8] net

CD40 Ligand/TRAP (Soluble)

PR27033 50 ug
EUR 608.4

Anti-TRAP alpha (1C11)

YF-MA15622 100 ug
EUR 435.6
Description: Mouse monoclonal to TRAP alpha

Anti-TRAP alpha (1A12)

YF-MA10883 100 ug
EUR 435.6
Description: Mouse monoclonal to TRAP alpha

VENT FILTER / C02 TRAP

ZFRE012FC EACH
EUR 440.04

TRAP-1 Antibody / HSP75

R32204 100 ug
EUR 419

CD40L Antibody / TRAP / CD154

RQ4070 100 ug
EUR 419

Cd40l Antibody / Trap / Cd154

RQ4071 100 ug
EUR 419

CD40L Antibody / TRAP / CD154

RQ4900 100ug
EUR 419

TRAcP Antibody / TRAP / ACP5

RQ5412 100 ul
EUR 419

CD40L Antibody / TRAP / CD154

V8248-100UG 100 ug
EUR 499
Description: CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

CD40L Antibody / TRAP / CD154

V8248-20UG 20 ug
EUR 219
Description: CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

CD40L Antibody / TRAP / CD154

V8248SAF-100UG 100 ug
EUR 499
Description: CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

TRAcP Antibody / TRAP / ACP5

F47709-0.08ML 0.08 ml
EUR 165

TRAcP Antibody / TRAP / ACP5

F47709-0.4ML 0.4 ml
EUR 379

TRAP-1 Antibody (HSP75)

F43545-0.08ML 0.08 ml
EUR 165

TRAP-1 Antibody (HSP75)

F43545-0.4ML 0.4 ml
EUR 379

CD154 Antibody / CD40L / TRAP

RQ6411 100 ug
EUR 419
Description: CD154 (CD40 ligand) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumour necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD154 with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since it is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb /IIIa receptor in patients with acute coronary syndromes was investigated. The soluble for of the protein may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells. CD154 plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.

Cd40l Antibody / Trap / Cd154

RQ6604 100ug
EUR 419
Description: CD40 ligand (CD40L) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumor necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD40L with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since CD40L is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb /IIIa receptor in patients with acute coronary syndromes was investigated. The soluble CD40L may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells. CD40L plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.

TRAP-1 Antibody / HSP75

RQ6811 100ug
EUR 419
Description: Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene. It is mapped to 16p13.3. This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. And this protein may function in regulating cellular stress responses. In addition, it was found that TRAP1 interacted with the N-terminal half of TNFR1. Also, TRAP1 interacted with the C-terminal ends of the proteins encoded by both multiple exostoses-causing genes, EXT1 and EXT2, but not with EXTL1 or EXTL3.

TRAcP Antibody / TRAP / ACP5

V2794-100UG 100 ug
EUR 499
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This mAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher's Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V2794-20UG 20 ug
EUR 219
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This mAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher's Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V2794SAF-100UG 100 ug
EUR 499
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This mAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher's Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V2795-100UG 100 ug
EUR 499
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This mAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V2795-20UG 20 ug
EUR 219
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This mAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V2795SAF-100UG 100 ug
EUR 499
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This mAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V3534-100UG 100 ug
EUR 499
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher’s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V3534-20UG 20 ug
EUR 219
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher’s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V3534IHC-7ML 7 ml
EUR 499
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher’s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V3534SAF-100UG 100 ug
EUR 499
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher’s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V3535-100UG 100 ug
EUR 499
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher’s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V3535-20UG 20 ug
EUR 219
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher’s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V3535IHC-7ML 7 ml
EUR 499
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher’s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V3535SAF-100UG 100 ug
EUR 499
Description: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher’s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

TRAcP Antibody / TRAP / ACP5

V7136-100UG 100 ug
EUR 499
Description: Tartrate-Resistant Acid Phosphatase is involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. [UniProt]

TRAcP Antibody / TRAP / ACP5

V7136-20UG 20 ug
EUR 219
Description: Tartrate-Resistant Acid Phosphatase is involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. [UniProt]

TRAcP Antibody / TRAP / ACP5

V7136SAF-100UG 100 ug
EUR 499
Description: Tartrate-Resistant Acid Phosphatase is involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. [UniProt]

CD40L Antibody / TRAP / CD154

V7385-100UG 100 ug
EUR 499
Description: CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

CD40L Antibody / TRAP / CD154

V7385-20UG 20 ug
EUR 219
Description: CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

CD40L Antibody / TRAP / CD154

V7385IHC-7ML 7 ml
EUR 499
Description: CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

CD40L Antibody / TRAP / CD154

V7385SAF-100UG 100 ug
EUR 499
Description: CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

CD40L Antibody / TRAP / CD154

V8828-100UG 100ug
EUR 499
Description: CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

CD40L Antibody / TRAP / CD154

V8828-20UG 20ug
EUR 219
Description: CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

CD40L Antibody / TRAP / CD154

V8828SAF-100UG 100ug
EUR 499
Description: CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit

CAS400A-KIT 1 kit (10 rxn)
EUR 1332

Pesticide Kit Containing All 10 Multi-Compound Mixes

SPXPR-KIT 1ML
EUR 1923.18

StemTAG Alkaline Phosphatase Staining Kit (Red)

CBA-300 100 assays
EUR 553.2
Description: Alkaline Phosphatase (AP) is a widely used marker for both mouse and human embryonic stem cells (ES) and embryonic germ cells (EG). Our StemTAG Alkaline Phosphatase kits provide an efficient system for monitoring cell differentiation or undifferentiation using the AP marker. The StemTAG Alkaline Phosphatase Staining Kits provide reagents for monitoring alkaline phosphatase activity via immunocytochemistry staining.

StemTAG Alkaline Phosphatase Staining Kit (Purple)

CBA-306 100 assays
EUR 553.2
Description: Alkaline Phosphatase (AP) is a widely used marker for both mouse and human embryonic stem cells (ES) and embryonic germ cells (EG). Our StemTAG Alkaline Phosphatase kits provide an efficient system for monitoring cell differentiation or undifferentiation using the AP marker. The StemTAG Alkaline Phosphatase Staining Kits provide reagents for monitoring alkaline phosphatase activity via immunocytochemistry staining.

Alcian Blue (pH 2.5) Staining Kit

AFR-1 250 ml ea.
EUR 249.6

Alcian Blue (pH 2.5) Staining Kit

AFR-2 30 ml ea.
EUR 153.6

CaspGLOW Active Caspase 12 Staining Kit

55R-1291 25 assays
EUR 338.4
Description: Caspase 12 Staining Kit for use activity in the research laboratory

CaspGLOW Active Caspase 2 Staining Kit

55R-1293 25 assays
EUR 340.8
Description: Caspase 2 Staining Kit for use activity in the research laboratory

CaspGLOW Active Caspase 3 Staining Kit

55R-1294 25 assays
EUR 355.2
Description: Caspase 3 Staining Kit for use activity in the research laboratory

CaspGLOW Active Caspase 8 Staining Kit

55R-1295 25 assays
EUR 355.2
Description: Caspase 8 Staining Kit for use activity in the research laboratory

CaspGLOW Active Caspase 9 Staining Kit

55R-1296 25 assays
EUR 355.2
Description: Caspase 9 Staining Kit for use activity in the research laboratory

CaspGLOW Red Active Caspase Staining Kit

55R-1297 25 assays
EUR 355.2
Description: Caspase Staining Kit for use activity in the research laboratory

Human Type I Collagen Staining Kit

9044 1 kit
EUR 406.26
Description: Human Type I Collagen Staining Kit

Yeast Viability Staining Kit (Green/Red)

31063-1 1kit
EUR 566.4
Description: Minimum order quantity: 1 unit of 1kit

Coomassie Brilliant Blue Gel Staining Kit

abx090653-1Kit 1 Kit
EUR 226.8

Hoechst 33342 / PI Double Staining Kit

abx097209-1Kit 1 Kit
EUR 292.8

Gel-FAST? Gel Staining/Destaining Kit

K901-40
EUR 210

Human FoxP3 Transcription Factor Staining Kit

OKTA00001 KIT
EUR 544.8
Description: Description of target: ;Species reactivity: ;Application: FC;Assay info: ;Sensitivity:

Human FoxP3 Transcription Factor Staining Kit

OKTA00004 KIT
EUR 544.8
Description: Description of target: ;Species reactivity: ;Application: FC;Assay info: ;Sensitivity:

CaspGLOW? Fluorescein Active Caspase Staining Kit

K180-100
EUR 660

CaspGLOW? Fluorescein Active Caspase Staining Kit

K180-25
EUR 280.8

Genorise® Alkaline Phosphatase Staining Kit

GR107045 100 tests
EUR 346.8

Lipid (Oil Red O) staining Kit

K580-24
EUR 542.4

Fluorescein Active Caspase-12 Staining Kit

K2046-100 100 assays
EUR 686.4

Fluorescein Active Caspase-12 Staining Kit

K2046-25 25 assays
EUR 285.6

Fluorescein Active Caspase-2 Staining Kit

K2048-100 100 assays
EUR 686.4

Fluorescein Active Caspase-2 Staining Kit

K2048-25 25 assays
EUR 285.6

Fluorescein Active Caspase-3 Staining Kit

K2049-100 100 assays
EUR 686.4

Fluorescein Active Caspase-3 Staining Kit

K2049-25 25 assays
EUR 285.6

Fluorescein Active Caspase-8 Staining Kit

K2050-100 100 assays
EUR 686.4

Fluorescein Active Caspase-8 Staining Kit

K2050-25 25 assays
EUR 285.6

Results: The cells formed spheroids well applied, and the addition of Noni in 10, 100 and 200 concentration ng / mL did not produce significant morphological changes. Quantitative values ​​for the survival of the mobile on day 3 showed that the values ​​of absorbance at 450 nm is 0.314 ± 0.013, 0.318 ± 0.008, 0.304 ± 0.000 and 0.300 ± 0.011 for Noni at 0, 10, 100 and 200 concentration ng / mL , each.

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